De-Risk Therapeutic Antibody Drug Development Using Humanized FcRn Platforms

Understanding the pharmacokinetics (PK) of lead compounds is crucial when selecting the best drug candidate for clinical, drug development. The humanized FcRn platform is an effective tool that can provide relevant PK data for antibodies and albumin-conjugated molecules. By utilizing humanized FcRn models, researchers can obtain valuable data to guide the lead optimization process and minimize the risks associated with candidate selection.

Join this webinar to learn more about this invaluable tool and how it can benefit your research. During this presentation, we will:

• Describe the biology of FcRn and its impact on immunoglobulin and albumin half-life
• Explain the advantages of utilizing the humanized FcRn platform for selecting immunoglobulin-based therapeutics in comparison to conventional in vitro and in vivo methodologies
• Discuss how to select and use specific humanized FcRn model variants for PK drug candidate evaluation

Webinar presenters

Kaya Ghosh, PhD
Technical Information Scientist II
The Jackson Laboratory

Charles River is the exclusive distributor of JAX^® Mice in Europe